CONTACT US

Circa Group Pty Ltd
34 Norfolk Court
Coburg North VIC 3058 Australia
Telephone +61 (3) 9354 3421
Twitter @circagroup

Tony Duncan
Chief Executive Officer
Tony.Duncan@circagroup.com.au

Warwick Raverty
Chief Scientist
Warwick.Raverty@circagroup.com.au

c/o Bio 21, Flemington Road
Melbourne
Australia

+61 419 303 117

Circa Group is converting waste biomass into advanced biochemical materials.

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Levoglucosenone

 

Levoglucosenone (CAS No. 37112-31-5) is recognised as a valuable product for two primary reasons:

  • the preservation of two of the natural chiral centres in cellulose that can be transferred into chiral therapeutic agents able to inhibit enzymatic reactions in viruses and other pathogens.
  • the α β-unsaturated ketone and protected aldehyde functionality in the levoglucosenone molecule offers the organic chemist a wide range of synthetic opportunities as a starting point for new molecules having fixed and known stereochemistry for anti-viral, anti-cancer and other bio-activity screening.

And with considerable published work on the use of levoglucosenone in drug development, commercial demand has been constrained by supply.

All attempts to commercially produce levoglucosenone have failed so far and generally the shortcoming is scale – reactions that can be conducted successfully on a micro-scale are frequently orders of magnitude less efficient when scaled up to practical levels because of problems associated with rates of heat transfer and extraction of the volatile product from the by-products.

Circa’s Furacell™ process allows efficient, industrial quantity production of levoglucosenone for the first time.